Core Synthesis Instrumentation

Metrohm 831 Coulometer Karl-Fischer Titrator: Determines very small amounts of water and gives an unmistakable presentation of the course of titration in form of a curve showing μg water against time.

MiniBlock XT: Flexible, easy-to-use reaction block designed for parallel synthesis and reaction screening.

VAC Solvent Purification and Drying Unit: Obtains dry solvents without the hazards of distillation stills.

Buchi Kugelrohr Distillation/Oven: Distills relatively small volumes of liquids with high boiling points under greatly reduced pressure.

CEM Microwave Reactor: High frequency electric fields provide an alternate form of rapid heating. Accelerated reaction rates, milder reaction conditions and higher chemical yields are its popular features.

Teledyne Isco Combi-Flash Rf 200i: Fast and efficient separation of small molecules. Automated collection of fractions, which are free of contamination. Uv-Visible and ELS detector. Milligrams to grams scale separation capability.

Waters HPLC/ Prep HPLC: Normal/Reverse phase separation of organic molecules using a binary pump and UV detector. Can also be used for analysis of chiral compounds.

Shared Equipment available for use by the CSASF:

  • Brucker Bio-TOF III High Resolution Mass Spectrometer
  • Agilent GC-Mass Spectrometer
  • Varian Inova 500 MHz NMR Spectrometer with triple axis gradients (actively shielded)
  • Varian Inova 400 MHz NMR Spectrometer with Z axis gradients
  • H-Cube Flow Hydrogenator